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As far as toxicity goes, there are actually no formal scientific tests on the lookout into it. Numerous assume four-acetoxy-dmt has an identical protection profile to psilocybin-containing mushrooms, but That is an assumption without having clinical data to back it up.
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This tolerance also applies to other classic psychedelics, and so, if you are taking something like LSD or psilocybin mushrooms inside of a week, the expertise can be a lot less pronounced than usual.